DNA Sequences Encoding Mammalian Alpha-1-Antitrypsin (AAT)
Tech ID: 01-82-01
Technology Description:
The inventors have isolated and sequenced cDNA encoding mammalian
Alpha-1-Antitrypsin, a protease inhibitor. AAT's physiological role is to
inactivate the enzymes that cleave proteins. Individuals lacking AAT suffer
obstructive respiratory disorders, such as emphysema, due to overactivity of
the protease, elastase. Currently, AAT isolated from human plasma is used to
treat emphysema. AAT may also have a therapeutic effect on a variety of other
obstructive respiratory condition and inflammatory disorders, including
dermatitis and psoriasis.
Application:
The cDNA may be used in the development of a recombinant AAT therapeutic or a
gene therapy.
Technology Offer:
The Washington Research Foundation is seeking commercial partners to develop
therapeutics based on the technology. License or option arrangements are
negotiable. US rights to the technology are available.
Patents/Publications:
Patents covering this technology include United States Patent No. 5,399,684,
which issued in March 1995, and United States Patent No. 5,736,379, which
issued in April 1998. An additional patent application is pending.
Development Stage:
The cDNA encoding normal AAT has been isolated sequenced by the inventors.
Competitive Advantage:
Purifying AAT from plasma for therapeutic use is labor-intensive and expensive,
and depends on a fluctuating supply of plasma. In addition, the plasma-derived
product has a short half-life, necessitating regular infusions. Production of a
recombinant AAT therapeutic would be less costly, less prone to contamination
by human pathogens, and not subject to fluctuations in the supply of raw
ingredients. Additionally, this cDNA may be integrated into a gene therapy
approach to disease treatment.
For additional information, please contact:
Beth G. Etscheid, Ph.D.
Director of Licensing
Washington Research Foundation
2815 Eastlake Avenue E, Suite 300
Seattle, WA 98102
Tel: 206.336.5600
Fax: 206.336.5615
betschei@wrfseattle.org
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